TLDR Tech / AI
Team uses AlphaFold AI to redesign gene-editing proteins to make them safer
A team based in China modified AlphaFold to help identify what parts of a gene-editing protein enable mistakes. They then modified these areas to reduce problematic off-target effects. Producing gene-editing systems tailored to prevent known off-target events is useful for fine-tuning protein-DNA interactions, which could have applications beyond gene editing.
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